The sperm chromatin structure assay as a diagnostic tool in the human fertility clinic
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چکیده
منابع مشابه
The sperm chromatin structure assay as a diagnostic tool in the human fertility clinic.
BACKGROUND Sperm DNA integrity has been shown to be necessary for achieving and sustaining embryo development. The objective was to evaluate the sperm chromatin structure assay (SCSA) as a diagnostic tool in clinical practice for intrauterine insemination (IUI), in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) treatments. METHODS A total of 385 semen samples from 234 c...
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Environmental toxicants cause sperm DNA fragmentation as detected by the Sperm Chromatin Structure Assay (SCSA).
Studies over the past two decades have clearly shown that reproductive toxicants cause sperm DNA fragmentation. This DNA fragmentation can usually be detected prior to observing alterations of metaphase chromosomes in embryos. Thus, Sperm Chromatin Structure Assay (SCSA)-detected DNA damage is viewed as the molecular precursor to later gross chromosome damage observed under the light microscope...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2006
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/del019